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DBCO-PEG5-NHS ester
CAS No. 2144395-59-3
DBCO-PEG5-NHS ester( —— )
Catalog No. M33335 CAS No. 2144395-59-3
DBCO-PEG5-NHS ester is a PROTAC linker belonging to the PEG and Alkyl/ether classes for the synthesis of a range of PROTAC molecules.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 170 | Get Quote |
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| 10MG | 250 | Get Quote |
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| 25MG | 408 | Get Quote |
|
| 50MG | 603 | Get Quote |
|
| 100MG | 839 | Get Quote |
|
| 200MG | 1143 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameDBCO-PEG5-NHS ester
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NoteResearch use only, not for human use.
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Brief DescriptionDBCO-PEG5-NHS ester is a PROTAC linker belonging to the PEG and Alkyl/ether classes for the synthesis of a range of PROTAC molecules.
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DescriptionDBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG5-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
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In Vivo——
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Synonyms——
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PathwayPROTACs
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TargetPROTAC
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RecptorPROTAC Linker
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Research Area——
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Indication——
Chemical Information
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CAS Number2144395-59-3
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Formula Weight693.74
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Molecular FormulaC36H43N3O11
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 100 mg/mL (144.15 mM)
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SMILESO=C(ON1C(=O)CCC1=O)CCOCCOCCOCCOCCOCCNC(=O)CCC(=O)N2C=3C=CC=CC3C#CC=4C=CC=CC4C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Craig L. Duvall, et al. Conjugation of lipophilic albumin-binding moiety to rna for improved carrier-free in vivo pharmacokinetics and gene silencing. US20180064749A1.
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